Gene

mettl5

ID

ZDB-GENE-041010-21

Name

methyltransferase 5, N6-adenosine

Symbol

mettl5 Nomenclature History

Previous Names

im:7137598
zgc:103655 (1)

Type

protein_coding_gene

Location

Chr: 9 Mapping Details/Browsers

Description

Predicted to have methyltransferase activity and nucleic acid binding activity. Predicted to be involved in methylation. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human METTL5 (methyltransferase like 5).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7137598 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Richard et al., 2019
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mettl5 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal recessive intellectual developmental disorder 72	Alliance	Intellectual developmental disorder, autosomal recessive 72	618665

Associated With mettl5 Via Experimental Models

Human Disease	Fish	Conditions	Citations
autosomal recessive intellectual developmental disorder 72	nl1Tg + MO2-mettl5	standard conditions	Richard et al., 2019
autosomal recessive intellectual developmental disorder 72	nl1Tg + MO1-mettl5	standard conditions	Richard et al., 2019

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR002052	DNA methylase, N-6 adenine-specific, conserved site
Domain	IPR007848	Methyltransferase small domain
Family	IPR051720	rRNA N6-Adenosine-Methyltransferase/Polyamine Synthase
Homologous_superfamily	IPR029063	S-adenosyl-L-methionine-dependent methyltransferase superfamily

Domain Details Per Protein

Protein	Length	DNA methylase, N-6 adenine-specific, conserved site	Methyltransferase small domain	rRNA N6-Adenosine-Methyltransferase/Polyamine Synthase	S-adenosyl-L-methionine-dependent methyltransferase superfamily
UniProtKB:F1QVR8 InterPro	207

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	mettl5-201 (1) Ensembl	Ensembl	1,090 nt	Select Tool ZFIN BLAST
mRNA	mettl5-203 (1) Ensembl	Ensembl	881 nt	Select Tool ZFIN BLAST
mRNA	mettl5-205 (1) Ensembl	Ensembl	5,511 nt	Select Tool ZFIN BLAST
ncRNA	mettl5-003 (1) Ensembl	Ensembl	814 nt	Select Tool ZFIN BLAST
ncRNA	mettl5-004 (1) Ensembl	Ensembl	779 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations